The Relationship Between Treatments and Recurrence in Borderline Ovarian Tumors [30A]

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Abstract

INTRODUCTION:

To evaluate the relationship between treatments and recurrence in borderline ovarian tumors.

METHODS:

In a retrospective study, 281 patients, from 2 institutions, with borderline ovarian tumors were investigated. The demographic, clinical and surgical characteristics of the cases were evaluated. The effects of type of surgery, surgical staging; complete or incomplete staging, lymph node removal, appendicectomy and chemotherapy on recurrence rates were calculated by using Kaplan-Meier method and multivariate Cox proportional hazards model analysis.

RESULTS:

This study investigated 281 patients who were finally diagnosed with borderline epithelial ovarian tumors. The median follow-up for survivors was 43.0 months (range, 5-237). Median time to recurrence was 41.0 months (range, 2-190). Twenty patients (7.1%) experienced relapse and 4 patients (1.4%) died of disease within the observations period. In multivariate analysis, removing ipsilateral ovary (HR: 0.074 [95% CI, 0.023-0.234], p=0.000), FIGO stage II-III (HR: 3.719 [95% CI, 1.418-9.749], p=0.008) and ovary surface involvement (HR: 9.720 [95% CI, 1.006-93.893], p=0.049) were independent prognostic factors on recurrence. The ovary surface involvement (HR: 64.996 [95%CI, 4.054-1041.941], p=0.003) was independent prognostic factor on OS.

CONCLUSION:

Our study reveals the impact of removing ipsilateral ovary, FIGO stage II-III and ovary surface involvement on the recurrence, and ovary surface involvement was co-related with overall survival. Patients presenting these risk factors should undergo closer follow-up.

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