Effects of Male Partner Age on Pregnancy and Obstetric Outcomes in Frozen Oocyte Donor Cycles [40N]

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Abstract

INTRODUCTION:

Nationally, paternal ages at conception are rising, as are concerns over potential risks in pregnancy and child health. It is unclear if advancing male age influences in vitro fertilization (IVF) success or obstetric outcomes. Frozen donor oocyte IVF offers an ideal model to study this, since oocytes come from young healthy women and intracytoplasmic sperm injection (ICSI) is performed. Thus, our objective was to examine whether paternal age affects outcomes in frozen donor oocyte IVF.

METHODS:

Data were analyzed from 852 patients undergoing embryo transfer derived from a vitrified oocyte donor bank between 2008-2015. Each recipient received a cohort of oocytes that were thawed, fertilized via ICSI, and transferred on post-fertilization day 5. Multivariate logistic regression was used to estimate rates of live birth (LBR), low birth weight (LBW), and preterm delivery (PTD) after the recipient’s first embryo transfer from the cohort.

RESULTS:

Mean age among male partners was 41.47+/-6.19 years. The LBR with male partner ages of <35, 36-40, 41-45, 46-50, and >50 years were 57.1%, 55.9%, 57.1%, 52,1%, and 56.3% respectively. After adjusting for covariates, male age was not associated with implantation, clinical pregnancy, or LBR. The rates of PTD ranged from 6.2-13.5% for male age <50. For men >50, PTD was elevated (33.3%), but this was not statistically significant after adjustment (aRR 2.49, 95% CI 0.84-7.39). The difference in LBW with men >35 was not statistically significant.

CONCLUSION:

Advancing male age is not associated with rates of live birth, low birth weight, or preterm delivery in frozen donor oocyte cycles.

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