Department of Obstetrics and Gynecology, Ruhr-Universität Bochum, Bochum, Germany.
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OBJECTIVE:To test whether music by Mozart reduces anxiety among patients undergoing colposcopy.METHODS:In a randomized multicenter trial, we measured the reduction of the situation-specific anxiety of women hearing Mozart’s Symphony No. 40 during colposcopy compared with women not hearing music using the State-Trait Anxiety Inventory. Secondary endpoints were reduction of heart rate (beats per minute), pain during and 10 minutes after colposcopy, general unpleasantness, anxiety during colposcopy, and overall satisfaction (11-item visual analog scales). Analysis was by intention to treat. A sample size of 104 per group (N=208) was calculated to achieve 80% power to detect a difference of 4.8 with a SD of 12.3 in anxiety scores.RESULTS:Between February 2017 and May 2018, 212 women were randomized. The mean anxiety reduction was −9.4±10.8 SD in 103 women in the music group and −9.0±10.6 in 102 women in the control group (P=.40). The secondary endpoints reduction of heart rate (−16.3±16.9 vs −15.4±17.1; P=.37), pain during procedure (median 2 [interquartile range 1–4] vs 2 [1–3.5]; P=.80), pain 10 minutes after examination (1 [0–1.75] vs 1 [0–2]; P=.42), general unpleasantness (3 [1–5.75] vs 4 [1–5.5]; P=.35), anxiety during examination (2 [1–5] vs 2 [1–6]; P=.28), and overall satisfaction (10 [9–10] vs 10 [9–10]; P=.81) were also not different between the two study groups.CONCLUSION:Mozart’s Symphony No. 40 does not reduce anxiety in women undergoing colposcopy.CLINICAL TRIAL REGISTRATION:ClinicalTrials.gov, NCT03005795.