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Two morbidly obese patients are presented. The first patient is a 38-year-old superobese female with BMI 56.2 in a wheelchair secondary to multiple sclerosis. The second patient is a 49-year-old female with BMI 47.7 confined to a wheelchair secondary to spinal cord transection due to a motor vehicle accident. Both patients underwent an open duodenal switch procedure, which provided significant weight loss and improved quality of life primarily for mobility with a wheelchair, as well as controlling comorbidities.