Lung cancer mortality in arsenic-exposed workers from a cadmium recovery plant

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Abstract

Background

There is evidence that arsenic is a late-stage human lung carcinogen.

Aims

To investigate lung cancer risks in a cohort of cadmium recovery workers in relation to period from ceasing exposure to arsenic.

Methods

The mortality experience (1940–2001) of a cohort of 625 male workers from a US cadmium recovery plant was compared with expectations based on US national mortality rates.

Results

There was a statistically significant (P < 0.05) negative trend in lung cancer standardized mortality ratios in relation to period from ceasing arsenic exposure.

Conclusions

The findings are consistent with the hypothesis that arsenic is a late-stage human carcinogen.

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