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The aim of this study was to evaluate the impact of an employee wellness program in Canada.A comprehensive program including web-based lifestyle challenges was evaluated with annual health screenings.Among 730 eligible employees, 688 (94%) registered for the program, 571 (78%) completed a health screening at baseline, and 314 (43%) at 1 year. Most (66%) employees tracked their activity for more than 6 weeks. At 1-year follow-up, there were significant clinical improvements in systolic blood pressure -3.4 mm Hg, and reductions in poor sleep quality (33% to 28%), high emotional stress (21% to 15%), and fatigue (11% to 6%). A positive dose–response was noted where the greatest improvements were observed among those who participated the most.The program had high employee engagement. After 1 year, the benefits included clinically important improvements in physical and mental health.