University of Toronto case–control study of multiple chemical sensitivity-3: intra-erythrocytic mineral levels

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BackgroundMultiple chemical sensitivity (MCS) has an estimated American prevalence of 15%, and no consistently abnormal laboratory tests are available to assist in its diagnosis. Some physicians treating MCS patients have observed changes in intra-erythrocytic minerals (IEMs). As co-factors, minerals could influence detoxication of xenobiotics.AimTo test whether IEM differed comparing MCS cases with controls.MethodsA total of 408 women meeting validated inclusion and exclusion criteria for MCS participated in this case–control study.ResultsNo statistically significant differences were observed. However, for copper, chromium, magnesium, molybdenum, sulphur and zinc, mean detectable levels were all lower in cases. No dose–response relationships were found.ConclusionIEM measurements do not appear to provide useful diagnostic markers for MCS.

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