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Multiple chemical sensitivity (MCS) has an estimated American prevalence of 15%, and no consistently abnormal laboratory tests are available to assist in its diagnosis. Some physicians treating MCS patients have observed changes in intra-erythrocytic minerals (IEMs). As co-factors, minerals could influence detoxication of xenobiotics.To test whether IEM differed comparing MCS cases with controls.A total of 408 women meeting validated inclusion and exclusion criteria for MCS participated in this case–control study.No statistically significant differences were observed. However, for copper, chromium, magnesium, molybdenum, sulphur and zinc, mean detectable levels were all lower in cases. No dose–response relationships were found.IEM measurements do not appear to provide useful diagnostic markers for MCS.