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To identify and describe experiences of patients with colorectal cancer (CRC) who have neurotoxic side effects early in the oxaliplatin treatment period, and how neurotoxicity affects their daily lives.10 patients with stage II-III CRC were included. All were treated with adjuvant oxaliplatin postoperatively and assessed neurotoxicity via a platform-independent mobile phone-based system. Patients were recruited from two hospitals in southern Sweden from November 2013 to August 2014.Qualitative interview study conducted through open-ended, face-to-face, qualitative interviews. Thematic analysis was used.A main theme was identified: “Endure neurotoxic side effects.” This theme illuminated how patients adapt to manage daily life. Patients' daily lives, as well as their psychosocial well-being, were affected. Patients changed their daily routines and reprioritized activities.Nurses have an obligation to communicate the importance of early detection of neurotoxicity. Mobile phone technology seems to be a valuable tool for monitoring patient-reported neurotoxicity to improve communication and supportive care.