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This study aimed to investigate whether the irritants used in bread and plastic industry cause irritation in the respiratory tract to determine the benefits of adding FeNO measurement method to periodical controls in various business branches.Our cross-sectional study was carried out 88 workers in the plastics and bread sectors in Istanbul. Our control group consists of 49 people. FeNO levels were measured and the relationship between these parameters and pulmonary function test parameters was investigated. When FeNO levels in control and work groups were investigated, they were found over 25 ppb in 8 persons working in bakery, 11 in plastics, and in 9 of the control group.When parameters related with respiratory function were evaluated, people whose parameters were found to be lower than 80% were as follows respectively: PEF levels of 29 people (64,4%) working in bakery in and FEF(25-75%) levels of 5 people (11,1%); whereas PEF values of 26 people (60,5%) among the workers of plastics and FEF(25-75%) levels of 5 people (11,6%) were found to be less than 80%. A statistical significance was found between FeNO and PEF levels which were under 80%. In workers whose FeNO levels were found under 25 ppb and those whose PEF levels were under 80% were found to be significantly high (p=0.03).Measuring FeNO levels will be helpful to identify the various environmental respiratory irritants at workplaces before they cause occupational illness. The widespread use of FeNO level measurement will be beneficial for the protection and development of workers’ health.