Rapid changes in working conditions constantly give rise to new occupational health risks and work-related diseases (WRDs). Monitoring these new WRDs is essential from the aspects of early recognition and prevention. In addition, it requires a comprehensive approach, using several complementary methods. One of these methods are early warning systems designed to collect information on health effects in order to trigger interventions and prevention. These systems differ in characteristics, their ability to capture new WRDs and their link with prevention. Therefore, the aim of this study is to identify sentinel and alert systems for detecting new and emerging WRDs, describe their main characteristics, and set up a basic typology. In the first phase, we conducted an extensive scientific and grey literature review and we identified 75 surveillance systems covering 26 different countries. We set up a basic typology of these systems dividing them into four main groups: compensation-based systems (21), non-compensation related comprehensive systems (38), sentinel systems (12) and public health surveillance systems aimed at workers and non-workers (7). These systems further differed in type of WRDs, coverage, data collection, evaluation of work-relatedness; follow up of new/emerging risks, link with prevention etc. In the second phase, we chose a representative selection of 12 good practise examples to be described in-depth. Through a desk research and interviews with stakeholders, we gained additional insight into drivers and obstacles regarding these systems and usage of collected data for identification of WRDs, prevention and policy recommendations.