0234 Occupational exposure to n-hexane is associated with reduced fsh levels and also with prolonged menstrual cycles in mexican workers of reproductive age

    loading  Checking for direct PDF access through Ovid

Abstract

Introduction

Former studies in rodents and cell lines have demonstrated ovarian toxicity caused by n-hexane and/or 2,5-hexanedione (2,5HD). In women occupationally exposed to solvents, variables ”menstrual cycle period” and ”time for getting pregnant” have been longer compared with controls, without identifying a compound responsible for those effects.

Material and methods

We studied a group of Mexican women labouring in a shoe Factory (n=32). Individual environmental levels for seven compounds, included n-hexane, were measured. Also, urinary 2,5HD and seric FSH and anti-Müllerian hormone (AMH) as potential biomarkers of ovarian toxicity, in addition to a gyneco-obstetric history were obtained. We performed all tests and questionnaires in a reference group as well (n=32).

Results

Mean exposure levels to n-hexane (49.2±39.6 mg/m3) and toluene (30.8±24.5 mg/m3) were the highest observed. There were no significant differences in serum FSH and AMH concentrations between groups (p>0.05). Exposed group showed prolonged menstrual cycles (p=0.007) and augmented time for getting pregnant compared with controls (p=0.007). Also in the exposed group, signifcant correlations were observed between FSH levels and n-hexane (r=−0.34, p=0.028) as well as FSH and 2,5HD (r=−0.33, p=0.029).

Conclusions

n-hexane exposure may be responsible for a prolonged menstrual cycle. As judged by the correlations between FSH with n-hexane and 2,5HD this affection could be in the endocrine pathway rather than in the ovary itself. n-hexane could act as endocrine disruptor in women of reproductive age.

Related Topics

    loading  Loading Related Articles