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Musculoskeletal diseases (MSD) affect almost 30% of the global construction sector workforce. Recent studies have shown high risks in bricklayers, plasterers and carpenters. The main causes of MSD in construction workers are heavy lifting, repetitive movements and poor ergonomic working postures. However, there are no studies in Turkey assessing work-related MSD prevalence in the construction sector and related disability in work and daily life.The aim of this study is to examine the prevalence of musculoskeletal symptoms in manual handling construction workers active in the construction of new buildings for a city hospital in Ankara. The study includes assessing the work-relatedness of MSD. Subsequently the effect of MSD on disability is analysed.We plan a cross-sectional study using a questionnaire on sociodemographic characteristics, risk factors at work and employment conditions, work history, health status, the Nordic Musculoskeletal Questionnaire and disability as a consequence of work-related MSD, using a face-to-face interview method. The interviews will be performed by trained occupational health and safety specialists from the Public Health Institution of Turkey (PHIT).The study proposal has been approved by the PHIT and the construction company. Workers will be asked for informed consent.We planned that 1.200 people will be included in the study. The prevalence of work-related MSD and disability will be determined, stratified for occupational groups and socio-demographic variables.The main outcome is prevalence of work-related MSDs in construction workers studied and related disability in work and daily life. Interventions will be recommended for prevention.