0313 Mortality among norwegian smelter industry workers – a 55 year follow-up

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Ambient air pollution is associated with increased incidence and mortality of cardiovascular disease. Time-series studies have shown that a 10 µg/m3 increase in mean 24 hour PM2 concentration increases the relative risk for daily cardiovascular mortality by 0.4% to 1.0%. In recent years, increasing concerns have been levelled at the ultrafine component of PM. Ultrafine particles are formed during combustion of materials, and are therefore abundant in the furnace area of metal smelter plants.In connexion with an ongoing project concerning occupational exposure to fine and ultrafine particles and risk of cardiovascular disease, an update of two large smelter worker cohorts has been performed. Mortality data were received from the Norwegian Causes of Death register for the period 1960–2014. The combined cohort consisted of 19 660 men, with nearly 650 000 person-years of follow-up. Preliminary analyses showed that both total mortality (SMR 1.09, 95% CI 1.07–1.11) and mortality from all cardiovascular diseases (SMR 1.03, 95% CI 1.00–1.06) were significantly increased compared to the Norwegian general male population. Workers with employment in furnace work had total mortality SMR 1.18 (95% CI 1.15–1.21) and cardiovascular mortality SMR 1.09 (95% CI 1.04–1.14). Smelter workers with no furnace work had total mortality SMR 1.01 (95% CI 0.99–1.04) and cardiovascular SMR 0.99 (95% CI 0.95–1.02). The further data analyses are currently in progress.

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