458 Epidemiological study between type 2 diabetes and bone mineral density

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IntroductionIn Japan, many people over 65 years old are working now. However, elderly working people frequently face to getting lifestyle diseases, so it would be important to control lifestyle diseases. Among lifestyle diseases, diabetes mellitus (DM) is a popular in the world. On the other hand, Osteoporosis is also an important disease for elderly workers, because osteoporosis is a risk to get fracture. There are some reports indicated that fractures was frequently in workers with DM. However, it was also reported that bone mineral density (BMD) in type 2 DM patients was higher than non-diabetic persons. These reports were contradictory. Therefore, we planned to evaluate fracture risk and BMD of persons with type 2 DM comparing with healthy subjects.Material and methodWe recruited 183 persons with type 2 DM (detail: 101 males, 82 females) under informed consent. We excluded persons with type 1 diabetes, rheumatic diseases. We collected individual data (age, sex, BMI, fasting blood sugar, average fasting blood sugar, HbA1c value, post history of fracture) and measure BMD using ultrasonic bone mass measurement.ResultBMD decreased with age. And BMD was higher than healthy subjects (Male and Female).In male, there was a significant positive correlation between MBD and BMI.In female, a significant positive correlation was found between BMD and fasting blood sugar.We didn’t detect the difference concerning to fracture history between persons with DM and healthy persons.DiscussionWe indicated BMD of DM persons was higher than healthy subjects. In addition, BMD of female was a significant positive correlation with the fasting blood sugar. But we could not indicate higher fracture risk in DM persons. We are planning to check whether fracture frequently happened or not in persons with DM.

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