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Currently, Indonesia have been facing the triple burden of diseases including Communicable Diseases, Non Communicable Diseases, and Environmental/Occupational Accidents/Diseases. However, Occupational Diseases are still under reporting. This presentation is aimed to show the importance of the strengthening the regulation aspect toward a better Occupational Diseases Management.Article review of the practice of Occupational Diseases management, and the policy and regulation in relation with the Occupational Health and Safety in Indonesia were used to explore the implementation and its challenges.The National Workers Social Security Agency in 2015 compensated Occupational Accidents of 110.285 cases with spent the cost of IDR 661 Billion. However due to under diagnosed only less than 10 cases per year as the compensated cases of occupational diseases for 5 consecutive years, one of the weaknesses is the lack of regulation and guideline of Occupational Diseases Management. In 2014, Indonesian Government implemented the National Social Security included National Health Insurance and National Workers Social Security. 2016, the Ministry of Health of the republic Indonesia launched the Ministry Decree concerning Occupational Diseases management, and Threshold Limit Value of physicals and chemical exposures at the workplace.The regulation of Occupational Diseases management, and Threshold Limit Value of physicals and chemical exposures at the workplace as further guidance for the OHS professionals in practicing the improvement of the management and control of Occupational Diseases in the context of National Social Security and Universal Health Coverage in Indonesia.