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Malignant Pleural Mesothelioma (MMP) is a neoplasm with high mortality caused by exposure to asbestos. Patients with MMP have a short survival with a median of 9 months (4–18 months); the worldwide increase in MMP incidence and mortality is more than 120, 000 cases. In Mexico, it is estimated 500 cases of MMP per year; however, there are no survival studies for this cancer. The aim of this study was to perform a case survival analysis with MMP and to identify the factors related to it.From a case study (MMP) and controls conducted from 2011–2016 in 3 hospitals in Mexico City, performed a survival analysis with the Cox model to obtain the Hazard Ratio (HR) with MMP, tumour stage, age, sex and history of occupational exposure.Of the 187 cases of MMP incorporated, there was a median survival of 480 days (IQR: 239–750). A Cox model was performed obtaining an Hazard Ratio by age of 1.02 (95% CI: 1.006 to 1.04), by asbestos occupational exposure of 1.84 (95% CI: 0.95 to 3.59) and stage IV of 1.95 (95% CI: 1.34 to 2.85) adjusted by sex.We observed that survival results are similar to those reported in the literature, that the risk of dying from MMP increases with age, occupational exposure to asbestos and tumour stage. MMP is diagnosed in advanced stages, thus survival is short, so that it is fundamental to continue the research of molecular markers for early diagnosis and to offer a timely treatment to increase survival and quality of life of patients.