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Burnout is a work-related mental health problem and may cause long-term sickness absence. Return-to-work interventions for burned out employees on sick leave aim to prevent long-term work disability. This systematic review adresses 2 questions:Which return–to–work interventions for burned out employees on sick leave have been studied?What is the effect of these interventions on return to work?We performed a systematic literature review and searched Medline, CINAHL, EMBASE and Web of Science from Jan 1, 2000 to March 16, 2016. We searched for articles of return-to-work interventions for burned out employees on sick leave. We excluded studies of self-employed people and studies of employees suffering from mental health problems other than burnout. We conducted the review in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Outcomes were return to work and overall burnout symptoms.We identified 1578 articles after removal of all duplicates. Ten articles met inclusion criteria of which 5 were person-directed interventions, 2 were organisation-directed and 3 were a combination of both intervention types. None of the person-directed interventions caused a significant improvement in return to work. In contrast, the 2 organisation-directed and 2 of the 3 combined interventions did significantly improve return to work. All interventions had a positive effect on overall burnout symptoms.Although all interventions improved burnout symptoms, only the interventions that were (partly) organisation-directed had a positive effect on return to work. This finding is important in the development of return-to-work interventions for employees with burnout.