Association Between Use of Oral Fluconazole During Pregnancy and Risk of Spontaneous Abortion and Stillbirth

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Abstracted from JAMA 2016;315(1):58–67

Pregnant women are at increased risk of vaginal candidiasis due to the increased secretion of sex hormones. Although intravaginal formulations of topical azole antifungals are first-line treatment for pregnant women, oral fluconazole is often used despite limited safety information.

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