Vaginal Progesterone Prophylaxis for Preterm Birth (the OPPTIMUM Study): A Multicentre, Randomized, Double-Blind Trial

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(Abstracted from Lancet 2016;387:2106–2116)

Administration of vaginal progesterone or intramuscular 17α-hydroxyprogesterone caproate has been found to prevent preterm birth in women with a short cervix and to reduce neonatal mortality as reported by the Cochrane Library meta-analysis. However, data on medium and long-term outcomes after the neonatal period are lacking.

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