Positron Emission Tomography/Computed Tomography for Gynecologic Malignancies

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Positron emission tomography/Computed tomography(PET/CT) is widely used for gynecologic cancers. Objective: To determine when PET/CT should be used for gynecologic cancers. Evidence Acquisition: PubMed was reviewed for articles on PET/CT of all gynecologic cancers. National Comprehensive Cancer Network, Society of Gynecologic Oncology, and American College of Radiology guidelines were reviewed.


Whole-body PET/CT is useful for (1) initial staging of cervical and endometrial cancer, posttherapy assessment, radiation therapy planning, and posttreatment surveillance of cervical cancer, and (2) assessment of recurrence of cervical, endometrial, or ovarian cancer in the presence of symptoms. It is also useful for staging and recurrence of uterine sarcomas, and for staging of vulvar and vaginal cancer.


Positron emission tomography/Computed tomography is clinically valuable for a variety of gynecologic cancers. Relevance: PET/CT plays an important role in detection of initial disease and recurrence of gynecologic malignancies.

Target Audience

Obstetricians and gynecologists, family physicians.

Learning Objectives

After completing this activity, the learner should be better able to: Show appropriate indications for ordering a PET/CT for staging of the most common gynecologic cancers, including ovarian, endometrial, and cervical cancers; show appropriate indications for ordering a PET/CT for recurrence of the most common gynecologic cancers; and use PET/CT appropriately for more rare cancers such as uterine sarcoma and vulvar cancer.

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