Cell-Free DNA vs Sequential Screening for the Detection of Fetal Chromosomal Abnormalities

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(Abstracted from Am J Obstet Gynecol 2016;214:727.e1–727.e6)

Cell-free DNA (cfDNA) screening has shown high sensitivities and specificities for trisomy 21 and other common aneuploidies, thereby leading to a consideration for its use as a primary screening test. However, it has limitations, including the limited range of targeted aneuploidies and the failure to always provide a result.

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