Accurate Quantitation of Mitochondrial DNA Reveals Uniform Levels in Human Blastocysts Irrespective of Ploidy, Age, or Implantation Potential

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Abstract

(Abstracted from Fertil Steril 2017;107:34–42)

Changes in mitochondrial DNA (mtDNA) copy number correlate with several conditions, including aging, myopathies, neuropathies, diabetes, and cancer. Recent studies in human embryos suggested that conditions deviating from the steady state, such as aneuploidy, advanced maternal age, or chemically induced stress, associate with higher mtDNA content.

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