Has Noninvasive Prenatal Testing Impacted Termination of Pregnancy and Live Birth Rates of Infants With Down Syndrome?

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Abstract

(Abstracted from Prenat Diagn 2017;37:1281–1290)

Noninvasive prenatal testing (NIPT) for aneuploidy using cell-free DNA (cfDNA) has become widely available and popular for detection of Down syndrome (DS) because of its high sensitivity (99%) and specificity (99.5%). The acceptance of NIPT as an alternative to the first-trimester combined test has greatly reduced the use of invasive prenatal diagnostic testing.

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