Fetal Major Cardiac Defects and Placental Dysfunction at 11–13 Weeks’ Gestation

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(Abstracted from Ultrasound Obstet Gynecol 2018;51:194–198)

Major congenital heart defects (CHDs) are those that require invasive interventions within the first year following birth and are often associated with fetal growth restriction (FGR). A recent study on isolated major CHDs found evidence of impaired placental angiogenesis in the absence of impaired placental perfusion and function in pregnancies with fetal CHD.

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