Germline De Novo Mutation Clusters Arise During Oocyte Aging in Genomic Regions With High Double-Strand-Break Incidence


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Abstract

(Abstracted from Nat Genet 2018;50:487–492)Germline de novo mutations (DNMs) arise spontaneously in parental gametes and are both drivers of evolution and a common cause of sporadic disorders. The total number of DNMs is highly correlated with paternal age and with maternal age to a lesser extent.

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