Tumor-infiltrating B cells and T cells: Working together to promote patient survival

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We recently reported a novel cooperative relationship between tumor-infiltrating B cells and CD8+ T cells in ovarian cancer, leading to increased patient survival. Here, we discuss the mechanisms whereby B cells might enhance cellular immunity, including serving as antigen-presenting cells, organizing tertiary lymphoid structures and secreting polarizing cytokines. The enhancement of both B and T-cell responses may result in more potent and sustained antitumor immunity.

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