Targeting two co-operating cytokines efficiently shapes immune responses

    loading  Checking for direct PDF access through Ovid

Abstract

For simultaneously mobilizing the adaptive and innate immune system against cancer, we fused interleukin (IL)-2 and IL-12 to generate a dual cytokine moiety that is targeted to neoplastic lesions by an antibody-binding domain. This approach elicits a broader attack of the immune system against cancer than the use of each cytokine alone.

Related Topics

    loading  Loading Related Articles