Accuracy of Laser Placement With Frameless Stereotaxy in Magnetic Resonance-Guided Laser-Induced Thermal Therapy


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Abstract

BACKGROUND:As magnetic resonance-guided laser-induced thermal therapy (MRgLITT) becomes more accepted, there needs to be an evaluation of the techniques required to achieve accurate laser placement.OBJECTIVE:To report our experience with frameless stereotaxy and the ability to achieve accurate laser placements. We also evaluate the variables associated with proper placement.METHODS:We performed a retrospective analysis from 3 years of MRgLITT. Demographics and operational parameters, including trajectory length, target alignment error, registration error, and radial error were recorded and compared. Blinded review was used for completeness of ablation.RESULTS:In the study, 90 laser placements were evaluated for 72 cases. Trajectory length and target alignment error was 95.3 ± 26.0 mm and 0.7 ± 0.3 mm, respectively. Significant differences existed in registration error between 4 (0.6 ± 0.3 mm) and 5 (0.5 ± 0.2 mm) skull pins (P = .04), but no significant decreases in registration error as additional skull pins were registered. Fifteen laser placements resulted in subtotal ablations. The overall radial error using frameless stereotaxy was 0.9 ± 1.6 mm. In the study, 65% of lasers were exactly on the planned trajectory. Of the 30 that were not, the radial error = 2.6 ± 1.9 mm. Radial error of subtotal laser ablations was 0.5 ± 0.9 (range, 0-2.8 mm) and was not significantly different from 0.8 ± 1.7 (range, 0-7.1 mm) radial error of lasers with total ablations (P = .52). Lasers with radial error >0 mm resulted in an incomplete ablation in 26.7% of cases.CONCLUSION:Skull pin-based frameless stereotaxy for MRgLITT results in consistent accuracy, with the majority of cases resulting in complete ablations. A significant proportion of lasers with RE >0 mm still result in complete ablations.ABBREVIATIONS:ANOVA, analysis of varianceMRgLITT, magnetic resonance-guided laser-induced thermal therapyPAD, precision aiming deviceRE, radial errorRegE, registration errorSPGR, spoiled gradient echoTAE, target alignment errorTL, trajectory length

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