Corneal Thickness Differences between Sexes after Oxybuprocaine Eye Drops

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Abstract

Purpose

We aimed to analyze the corneal thickness (CT) values of female and male subjects before and after instillation of oxybuprocaine 0.4% anesthetic eye drops.

Methods

The CT of 30 female subjects and 28 male subjects was measured using scanning-slit corneal topography (Orbscan Topography System II, Orbscan, Inc, Salt Lake City, UT). Measurements were carried out before and 3 minutes after the instillation of oxybuprocaine 0.4% eye drops.

Results

The difference between the baseline values and those obtained after anesthesia ranged as follows: male subjects: central, −26 to +24 μm; superior, −24 to +23 μm; inferior, −19 to +20 μm; nasal, −25 to +30 μm; and temporal, −21 to +20 μm; female subjects: central, −16 to +24 μm; superior, −19 to +32 μm; inferior, −14 to +34 μm; nasal, −19 to +33 μm; and temporal, −36 to +16 μm. No significant differences were found in any corneal location in male subjects. The differences were significant at inferior (p = 0.001) and nasal (p = 0.011) corneal sites in female subjects.

Conclusions

Oxybuprocaine anesthetic eye drops induce significant CT increases in female subjects but not in male subjects.

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