Intraoral digital imaging documenting recurrent aphthous ulcer healing in 2-octyl cyanoacrylate versus sham-treated lesions


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Abstract

Objective.A device to standardize imaging was coupled with a digital intraoral camera to investigate the efficacy of 2-octyl cyanoacrylate (OC) tissue adhesives on the healing of minor aphthous ulcers.Study design.Forty-two subjects were enrolled in a patient-blinded, sham-controlled study assessing the effects of 2-OC formulations on ulcer size and healing time. Daily images were made until ulcers were healed. Ulcer image outlines were traced by using a mouse, and ulcer areas were automatically calculated.Results.A mean difference of –0.15 mm2 was seen between baseline and next-day measurements (P = .48). The cumulative ulcer area was meaningfully reduced in one OC group compared with the sham group (P = .04). Time to healing was reduced by 1.9 days in the same group compared with the sham group (P = .02).Conclusions.The use of digital intraoral images with an integrated measurement reference enhances the accuracy and reproducibility of measurements. 2-OC adhesives hold promise as devices to promote healing of recurrent aphthous ulcers. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;89425-31)

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