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To evaluate wound healing of incisions created by steel scalpel (with and without the application of N-butyl-2-cyanoacrylate) and cryosurgery.Prospective blinded and randomized study. Adult albino rats (N = 93) were randomly assigned to 3 groups (31 animals per group) before making incisions on oral mucosa by steel scalpel (2 groups) or cryosurgical techniques (remaining group). No product was applied to the resulting wound in the first group, while N-butyl-2-cyanoacrylate was applied to the wounds made in the tongues of the second group. Hemostasis, postoperative oral intake, and wound healing were measured. Statistical analysis was performed using analysis of variance.The wounds to which N-butyl-2-cyanoacrylate had been applied showed no hemorrhaging and faster reepithelialization and resolution of the inflammatory response, and the animals gained weight more rapidly.N-butyl-2-cyanoacrylate is a good hemostatic for managing wounds in the oral mucosa provoked by steel scalpel.