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The purpose of this study was to compare differences in the healing process in the sinus bone grafting using various grafting materials.Maxillary sinus bone grafts were divided into 4 groups according to the graft material used: group I, a mixture of autogenous bone and BioOss (Osteohealth Co., Shirley, NY); group II, a mixture of BioOss and Orthoblast II (Greencross; Isotis); group III, BioOss only; and group IV, synthetic bone, Osteon (Genoss, Korea), only. To evaluate the healing status of the graft surgery, bone specimens were collected from the lateral sinus using a 2.0-mm trephine bur at 4 and 6 months after surgery. Histology of the bone specimens was prepared, and the percentage of newly formed bone fraction, lamellar bone/woven bone ratio (LB/WB), and newly formed bone/graft material ratio (NB/GM) were measured to indicate the suitability of the materials and the healing of the grafts.The LB/WB ratio and NB/GM ratio were markedly increased at 6 months compared with the values at 4 months. It was observed that good bone healing was achieved even for grafts of xenogeneic bone only or synthetic bone only. Cases grafted with a mixture of allogeneic and xenogeneic bone showed no great advantage regarding bone healing.The results indicated that grafts of xenogeneic or synthetic bone can be effective for sinus bone grafting.