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Variations in root number and canal morphology are challenges for successful endodontic therapy. This report describes 2 endodontically managed maxillary first molars with asymmetric presentation of unusual palatal root morphology. These included the left maxillary first molar with a single palatal root and 2 palatal canals and the right maxillary first molar with 2 separate palatal roots with 1 canal in each root. An accurate diagnosis was confirmed with the help of spiral computerized tomography. This case report discusses this asymmetric variation in the palatal root morphology and highlights the value of spiral computerized tomography in diagnosis of such unusual cases.