CD8 T cells and E-cadherin in host responses against oropharyngeal candidiasis

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Background:Oropharyngeal candidiasis (OPC) is the most common oral infection in HIV+persons. Previous studies suggest a role for CD8+T cells against OPC when CD4+T cells are lost, but enhanced susceptibility to infection occurs when CD8+T-cell migration is inhibited by reduced tissue E-cadherin.Objective:To conduct a longitudinal study of tissue CD8+T-cells and E-cadherin expression before, during, and after the episodes of OPC.Methods:Oral fungal burden was monitored and tissue was evaluated for CD8+T cells and E-cadherin over a 1-year period in HIV+persons with a history of, or an acute episode of, OPC.Results:While longitudinal analyses precluded formal interpretations, point prevalence analyses of the data set revealed that when patients experiencing OPC were successfully treated, tissue E-cadherin expression was similar to that in patients who had not experienced OPC, and higher numbers of CD8+T cells were distributed throughout OPCtissue under normal expression of E-cadherin.Conclusion:These results suggest that (1) reduction in tissue E-cadherin expression in patients with OPC+is not permanent, and (2) high numbers of CD8+T cells can be distributed throughout OPCtissue under normal E-cadherin expression. Together, these results extend our previous studies and continue to support a role for CD8+T cells in host defense against OPC.Oral Diseases (2012) 18, 153–161

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