IL1gene polymorphisms in relation to external apical root resorption concurrent with orthodontia

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External apical root resorption (EARR) is permanent shortening of the end of the tooth root. It is a common clinical complication of orthodontic treatment. Polymorphisms in the interleukin 1 (IL1) gene cluster have been related to an increased EARR risk. The aim of this study was to analyze possible associations ofIL1gene variants with EARR in Czech population.


In this case–control study, 32 patients with EARR (age 15.0 ± 4.1 years) and 74 controls (age 15.2 ± 5.3 years) were genotyped using PCR-based methods forIL1A(−889C/T),IL1B(+3953C/T), andIL1RN[IL1receptor antagonist, variable number tandem repeat (VNTR)] gene polymorphisms.


While no statistical significant differences in theIL1AandIL1Bgenotype, allele and reconstructedIL1haplotype frequencies between patients with EARR and controls were found, marginally significant differences were observed in the frequencies ofIL1RNvariant (P= 0.05 for *22 genotype andP= 0.06 for a short (2) allele). In addition, significant associations betweenIL1RN*12, *22 genotypes and the short (2) allele and EARR were identified in the subgroup of girls (P= 0.04 andP= 0.02,P= 0.02).


Although no significant role ofIL1A(−889C/T) andIL1B(+3953C/T) variants in EARR was confirmed,IL1RNVNTR may be associated with EARR, especially in girls.

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