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Enoxacin and ciprofloxacin, which are new oral quinolone derivatives, can provide an alternative treatment for patients with osteomyelitis. In the past, chronic osteomyelitis required 6–8 weeks of intravenous (IV) antibiotic therapy. These two oral antibiotics have the potential to decrease hospital days and reduce the cost of home care. Oral ciprofloxacin has been in use since the fall of 1987. Enoxacin remains an investigational drug, and FDA approval is expected soon.