DQA1 and DQB1 association and nasal polyposis

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OBJECTIVE:The aim of this study was to determine the contribution of the human major histocompatibility complex (HLA)-DQA1, –DQB1, and TNFα genes with simple nasal polyposis.STUDY DESIGN AND SETTING:A comparative case-control study with 31 patients and 151 controls was performed. HLA-DQA1, –DQB1, and TNFα -238 promoter position loci were typed by polymerase chain reaction (PCR) and sequence specific oligonucleotide probes (SSOPs). TNFα -308 promoter position was determined by PCR and digestion with NcoI restriction enzyme.RESULTS:The allele HLA-DQA1*0201 (Pc = 0.019) had an etiologic fraction (EF) of 17%, whereas 13% EF was found for the haplotype HLA-DQA1*0201-DQB1*0201 (P = 0.016). Analysis of -DQB1 and TNFα promoter did not show significant differences between cases and controls.CONCLUSIONS:HLA-DQA1*0201-DQB1*0201 haplotype is involved in susceptibility, conferring 5.53 times more risk of developing this disease.EBM rating: B-2b

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