Implications of Synkinesis in Unilateral Vocal Fold Paralysis

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In patients with unilateral vocal fold paralysis (UVFP), laryngeal electromyography (LEMG) occasionally observes synkinesis in laryngeal muscles, a condition that could impair vocal fold mobility and voice control. This study aims to evaluate the impact of synkinesis on UVFP patients.

Study Design

A retrospective case-control study.


Medical center.

Subjects and Methods

Patients with UVFP onset >6 months were recruited (N = 104). The outcome measurements included LEMG, quantitative LEMG analysis of thyroarytenoid–lateral cricoarytenoid (TA-LCA) muscle complex, glottal gap measured by videolaryngostroboscopy, voice-related quality of life, and voice acoustic analysis.


According to the LEMG analysis, 8 patients (8%) had synkinesis, and 96 (92%) did not. In the synkinesis group, TA-LCA turn frequency in the lesioned side was comparable to that in the healthy side (P = .52). Patients in the synkinesis group had higher TA-LCA turn frequency (P = .001), higher probability of cricothyroid muscle dysfunction (P = .04), and better voice-related quality of life (P = .01) but objective voice outcomes comparable to those in the nonsynkinesis group.


Patients with synkinesis will have near-complete restoration in TA-LCA turn frequency but still experience voice impairment, a finding that is compatible with the mechanism of aberrant reinnervation. However, patients with synkinesis have better disease-related quality of life than do those without synkinesis.

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