Salivary glands sarcoidosis

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Abstract

Sarcoidosis is chronic multisystem disease of unknown etiology. It is characterized by non caseating granulomas in the involved organs. Lung involvement is the most common organ involvement. Other common manifestations include skin, joint and ocular lesions. Otolaryngologic manifestations are seen in 10-15% of sarcoidosis patients. Sarcoidosis of the salivary glands present with a painless and persistent enlargement of the parotid glands. Xerostomia is often present. A second presentation is uveo parotid fever or Heerfordt's syndrome. The diagnosis of sarcoidosis is made when there is a histological evidence of non caseating granulomas in the absence of infection and malignancy. There are no FDA approved therapies for sarcoidosis. Corticosteroids remain the standard of care. Corticosteroid sparing agents may be used in patients with progressive disease. The use of tumor necrosis factor inhibitors may be effective in refractory cases.

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