Genes involved in the 5-hydroxytryptamine (5-HT) system have been considered as potential candidates for creativity. The present study systematically explored the associations of 5-HT–related tryptophan hydroxylase (TPH) genes with creative potential in the Han Chinese population. Twenty-five single-nucleotide polymorphisms (SNPs) covering TPH1 and TPH2 were genotyped in 543 unrelated healthy Chinese undergraduates whose creative potentials were assessed by divergent thinking (DT) tests. Both single SNP and haplotype analysis revealed several novel associations of SNPs and haplotypes with various DT indexes, although the previously reported association of TPH1 rs1799913 polymorphism with creative potential was not replicated. In conclusion, the present study provides preliminary evidence for the involvement of TPH in creative potential, but further studies are necessary to validate these findings.