Superficially Invasive Squamous Cell Carcinoma of the Uterine Cervix: The Assessment of Key Parameters

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A variety of terms have been used over the years to define a set of early invasive squamous carcinomas of the uterine cervix that can be treated by local excision only. The Lower Anogenital Squamous Terminology consensus group has recommended that the term “superficially invasive squamous cell carcinoma” (SISCCA) be used for any genital invasive squamous carcinoma that can be managed by local excision only. The definition of SISCCA varies by genital site. A diagnosis of SISCCA of the uterine cervix requires that the invasive lesion was not visualized, has been completely excised, has a depth of invasion no more than 3 mm, and has a horizontal extent of no more than 7 mm. Lymphovascular invasion may or may not be present and should be noted. Superficially invasive squamous cell carcinoma of the uterine cervix is synonymous with an International Federation of Gynecology and Obstetrics stage IA1 carcinoma. This review addresses morphologic challenges that can be seen in the diagnosis of SISCCA including the identification of early invasion, measurements of depth and horizontal extent, and the assessment of circumferential involvement and margin status.

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