De Novo CD5+ Diffuse Large B-Cell Lymphoma With Cutaneous Involvement

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De novo CD5+ diffuse large B-cell lymphoma (DLBCL) is rare but distinctive clinicopathologic variant of DLBCL mainly affecting elderly people, showing female predilection and characterized by poor survival and outcome with conventional therapy. The main differential diagnoses include secondary CD5+ DLBCL (acquisition of CD5 expression during the progression of DLBCL or follicular lymphoma), large cell transformation in B-cell chronic lymphocytic leukemia (Richter syndrome), and mantle cell lymphoma. Extranodal involvement is often seen, but cutaneous involvement in this lymphoma variant is unusual.

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