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Many factors can affect the pressure pain threshold in the elderly population, especially those with cognitive impairment. The purpose of this study was to assess the pressure pain threshold (PPT) and its correlation with depression and anxiety status in geriatric nursing home residents with cognitive impairments. This study included 20 elderly subjects with cognitive impairment and 13 with normal cognitive functions. Cognitive function was assessed by Mini-Mental State Examination test. PPT of masseter and biceps brachii muscles were measured. Also, Geriatric Depression Scale (GDS) and Hamilton Anxiety Rating Scale (HAM-A) were used for screening depression and anxiety, respectively. PPT values did not differ significantly between the two groups. In the group with cognitive impairment, PPT and, depression and anxiety were not correlated. In subjects with normal cognitive function, PPT was positively correlated with depression and negatively with anxiety (p < 0.05). Subjects with cognitive impairment were found to be more depressed and anxious (p < 0.05).