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Neck pain is assumed to be a multifactorial entity, and several investigators have suggested that some psychological areas emerge in neck pain.The aim of the current study is to isolate psychopathological and personality factors to achieve progress in patients with cervical pain undertaking a rehabilitation programme.120 outpatients attending consecutively a rehabilitation clinic were initially selected. They had neck pain, shoulder pain and neck-and-shoulder pain. We evaluated, at baseline and endpoint, pain symptoms (West Haven-Yale Multifactorial Pain Inventory), personality traits (Eysenck Personality Questionnaire-A), and psychological status (Symptom Checklist-90-Revised). Two dimensions related to rehabilitation treatment were considered: severity of pain and severity of psychopathology.The rehabilitation programme relieves pain and psychological discomfort. Interference and pain severity are risk factors for pain after treatment. Gender, psychoticism, anxiety, and interpersonal sensitivity are risk factors for psychological discomfort after treatment.The presence of clinical predictors at a psychopathological and pain status gives weight to the importance of assessing symptoms of psychological distress in patients with neck pain.