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Permanent neurological complications following epidural anaesthesia are very rare. In this report, we present a patient who had permanent neurological deficit after multiple single-shot epidural injections. The patient lost sensation to light touch, temperature, pinprick and vibration below the level of Th10 in the left side. Proprioceptive sensation remained intact only on her right side. The left leg was flaccid and motor function in the leg was completely lost. Spinal cord infarction was confirmed by magnetic resonance imaging. Although this complication is very rare, caution should be exercised in patient selection when using epidural anaesthesia in the presence of risk factors.