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To investigate the association between 308 G/A polymorphism of TNF-α gene and migraine.Polymerase chain reaction-restriction fragment length polymorphism assay was used to determine TNF-308 G/A polymorphism in 60 migraineurs and 62 healthy controls.There was no significant relationship between TNF-α–308 G/A polymorphism and gender, family history of epilepsy, family history of migraine and aura. In the control group, the frequencies of G and A alleles were 0.93 and 0.07, respectively. The corresponding values were 0.94 and 0.06 in the migraineurs. There was no significant difference between the allele frequencies and genotypes of the migraineurs and controls (p = 0.85).TNF-α–308 G/A polymorphism is not associated with migraine and aura.