Histopathologic changes in liver induced by diclofenac and ketorolac after isoflurane anesthesia in rabbits


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Abstract

summaryObjectiveWe studied the postoperative effects of diclofenac and ketorolac on the histopathology of liver in rabbits that had undergone isoflurane anesthesia.MethodsThe rabbits were divided into three treatment groups: control group (C), diclofenac group (D) and ketorolac group (K) each comprised 10 rabbits. Three ml 0.9% NaCl in group C, 10 mg kg−1 in group D, 10 mg kg−1 in group K were administered twice a day for three days. At the end of the experimental period, animals were sacrificed, autopsied and liver tissue samples were prepared for histopathologic assessment.ResultsHepatocyte degeneration, sinusoidal dilatation, central vein dilatation, enlargement of the periportal area, mononuclear cell infiltration, pleomorphism of hepatocytes, limiting plate irregularities, increased fibrous tissue and bile duct proliferation were observed in group D. Central vein dilatation, enlargement of periportal area, mononuclear cell infiltration, hepatocyte degeneration, sinusoidal dilatation, bile duct proliferation, and pleomorphism of the hepatocytes were observed in group K. In addition, hepatocytes with eosinophilic cytoplasm and pyknotic nucleus were more evident in group K than in group D.

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