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Linear polarized near-infrared irradiation around the stellate ganglia (Lizer-SGB) is thought to have a similar effect to stellate ganglion block (SGB), namely, a reduced effect on stress. The effect of Lizer-SGB on various hormone levels was examined. Six adult male volunteers received bilateral Lizer-SGB, and blood was collected before and after this treatment, followed by measurements of plasma adrenocorticotropic hormone (ACTH) and serum cortisol (CS), luteinizing hormone (LH), testosterone (TS), thyroid stimulating hormone (TSH), triiodothyronine (T3) and thyroxine (T4). On a different day, the same measurements were taken from volunteers in the absence of irradiation. The results showed that ACTH, LH, TS and T4 levels were similar in treated and non-treated groups, whilst CS levels decreased after Lizer-SGB. Although TSH and T3 levels decreased, their values were not changed as a specific effect of Lizer-SGB. The results obtained showed that Lizer-SGB has an effect similar to SGB, regarding stress reduction.