Induction of Cell Proliferation and Differentiation in the Pancreas of the Adult Vervet Monkey (: Preliminary ResultsCercopithecus aethiops: Preliminary Results): Preliminary Results

    loading  Checking for direct PDF access through Ovid



Cellophane wrapping of the adult Syrian golden hamster pancreas has been found to result in ductular cell proliferation leading to islet regeneration. Injection of cytosol from a cellophane-wrapped pancreas into normal or diabetic hamsters evoked a similar response. In view of the therapeutic potential of the active substance in this cytosol, it was decided to investigate whether a similar response could be achieved in a primate. In normal adult Vervet monkey (Cercopithecus aerhiops) pancreas, proliferation is seen only rarely in islet cells and occasionally in duct and acinar cells. Immunohistochemi-cal investigation of normal Vervet monkey pancreas (n = 4) and 14 days (n = 2) and 56 days (n = 1) after cellophane wrapping of the Vervet monkey pancreas revealed a slight increase in proliferation of islet and acinar cells and a larger increase in proliferation of duct cells and in total endocrine cell volume. The results suggest that there is a latent developmental capability in the adult primate pancreas.

Related Topics

    loading  Loading Related Articles