ImmunoglobulinVHgenes in thymic MALT lymphoma are biased toward a restricted repertoire and are frequently unmutated


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Abstract

Thymic MALT lymphoma shows certain distinctive features among MALT lymphomas, such as expression of IgA isotype, consistent lack ofAPI2–MALT1gene fusion, and very strong association with autoimmune disease, especially Sjogren's syndrome. To help clarify the nature of the clonal lymphoid infiltrates, we analysed the usage and somatic hypermutation of the Ig heavy chain variable region (VH) genes in nine different cases. TheVHrearrangement was potentially functional in all cases and was restricted to theVH3family.VHusage was biased towardVH3-30(five cases) andVH3-23(three cases) segments, which have both been frequently expressed by autoimmune B cells. Somatic hypermutation was absent in five cases. Fewer than the expected replacement mutations were found in the framework regions in two cases, indicating a negative antigen selection pressure. Ongoing mutation was absent in all cases.Dsegment usage was varied, whereasJHsegment usage was restricted toJH4. The observed patterns ofVHusage and mutations suggested that specific antigens may play a pathologically relevant role in the genesis or progression of thymic MALT lymphoma. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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